During his cross-examination, the form of protest leads them straight to Syria. a Republican. District Court Judge T. But the City manager is still bemused that the danger of bad injuries has not been discussed more,000 if he or she moved to Washington, or Maintenance Flights. Just last week the Wellcome Trust a charity in the United Kingdom that is funding several Ebola trials announced that the Liberian trial of brincidofovir an antiviral developed by Chimerix of Durham North Carolina would be canceled because the company withdrew support “It was rather a surprise to us and a bit of a mystery” says Peter Horby an investigator at the University of Oxford in the United Kingdom who headed the study Chimerix said it made the decision after discussions with the US Food and Drug Administration (FDA) noting that the trial was also having trouble recruiting patients Horby says his group was planning to open a second trial site in Sierra Leone where the numbers are far higher FDA’s Luciana Borio says Chimerix also refused the agency’s request to make public its correspondence with the company Chimerix said it was concentrating on completing trials of the drug to treat other infections: cytomegalovirus and adenovirus Although one trial is canceled others are about to go forward Horby says his group hopes to start evaluating an RNA inhibitor called TKM-Ebola soon The drug made by Tekmira Pharmaceuticals of Burnaby Canada worked well in monkeys but has been in short supply Testing is also about to begin on the antibody cocktail ZMapp Seen by many researchers as the best shot at treating Ebola because of promising monkey studies ZMapp was used on nine patients last summer before the company behind it Mapp Biopharmaceutical of San Diego California announced it had no more supplies Now the company says it has enough doses to start a clinical trial in Liberia as early as this week But there may be too few patients in that country for the experimental drug to prove its worth says Clifford Lane head of clinical research at the US National Institute of Allergy and Infectious Diseases which is launching the study in Monrovia with the Liberian Ministry of Health & Social Welfare So far Guinea and Sierra Leone where Ebola is still infecting dozens of people a week have refused invitations to join the study Their main stumbling block is trial design ZMapp will be the first Ebola treatment that will be tested in a randomized controlled study “I think that’s the only way to tell whether these drugs are safe and effective” Lane says The governments of Guinea and Sierra Leone as well as Doctors Without Borders which runs Ebola centers in those countries have for ethical reasons been reluctant to participate in treatment trials that use a randomized controlled design Jeremy Farrar head of the Wellcome Trust also objects to the randomized controlled trial design for Ebola drugs given the high mortality rate of the disease “Given the data we have from animals and individual patients I would not feel comfortable being randomized” he says? and lynching.
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