California Raisins’ innovation competition

first_imgCalifornia Raisins is inviting bakers to take part in its 2009 Innovation competition. It aims to find the most innovative new products that have been created using California Raisins, California Raisin paste or California Raisin juice concentrate.The product can be anything at all as long as it contains California Raisins. The winning business will receive thousands of pounds worth of advertising for the product, as well as free PR for the company.For an entry form or further information please contact the California Raisin Administrative Committee at [email protected], or visit closing date for entries is the 31 March 2009.last_img

Exercise can ‘clean up’ Alzheimer’s environment

first_img Plotting the demise of Alzheimer’s New study is major test for power of early action Exposure to new activities may delay onset of dementia Environment counts, Alzheimer’s research suggests Choi explained, “We found the key difference was that exercise also turned on the production of brain-derived neurotrophic factor, or BDNF — known to be important for the growth and survival of neurons — which created a more hospitable brain environment for the new neurons to survive. By combining drugs and gene therapy that both induced neurogenesis and increased BDNF production, we were able to successfully mimic the effects of exercise on cognitive function.” Choi is an assistant professor of neurology at Harvard Medical School (HMS).Tanzi added, “The lesson learned was that it is not enough just to turn on the birth of new nerve cells; you must simultaneously ‘clean up’ the neighborhood in which they are being born to make sure the new cells survive and thrive. Exercise can achieve that, but we found ways of mimicking those beneficial cognitive effects by the application of drugs and gene therapy that simultaneously turn on neurogenesis and BDNF production.”In another part of the study, the investigators found that blocking neurogenesis in Alzheimer’s mice shortly after birth led to more pronounced cognitive deficits later in life. “We will next explore whether safely promoting neurogenesis in Alzheimer’s patients will help alleviate the symptoms of the disease and whether doing so in currently healthy individuals earlier in life can help prevent symptoms later on,” said Tanzi, the Joseph P. and Rose F. Kennedy Professor of Neurology at HMS. “We are very excited to now investigate ways of implementing our new findings to more effectively treat and prevent this terrible disease.”Additional co-authors of the Science paper are Enjana Bylykbashi, Zena Chatila, Eunhee Kim, Alexander Rompala, Mary Oram, Caroline Asselin, Jenna Aronson, Can Zhang, Sean Miller, Andrea Lesinski, and Doo Yeon Kim, Genetics and Aging Research Unit, MGH Neurology; Benjamin Pulli and John W. Chen, MGH Radiology; Star W. Lee, Gregory Clemenson, and Fred H. Gage, Salk Institute for Biological Studies; Henriette van Praag, Florida Atlantic University; and Bruce M. Spiegelman, Dana-Farber Cancer Institute.The study was supported with grants from the Cure Alzheimer’s Fund, the JPB Foundation, the Mathers Foundation, the Leona M. and Harry B. Helmsley Charitable Trust, and National Institutes of Health grants R01 MH060009, 1RF1 AG048080-01 and 2R01 AG014713. Related Their experiments showed that AHN could be induced in the model either by exercise or by treatment with drugs and gene therapy that promoted the birth of neural progenitor cells. Behavioral testing on animals revealed limited cognitive benefits in animals in which neurogenesis had been induced pharmacologically and genetically. But animals in which AHN was induced by exercise showed improved cognitive performance and reduced levels of beta-amyloid, the main component of plaques in Alzheimer’s brains.“Although exercise-induced AHN improved cognition in Alzheimer’s mice by turning on neurogenesis, trying to achieve that result by using gene therapy and drugs did not help,” Tanzi said. “That was because newly born neurons, induced by drugs and gene therapy, were not able to survive in brain regions already ravaged by Alzheimer’s pathology, particularly neuroinflammation. So we asked how neurogenesis induced by exercise differs.” A study by a Massachusetts General Hospital (MGH) research team finds that neurogenesis — inducing the production of new neurons — in the brain structure in which memories are encoded can improve cognitive function in a mouse model of Alzheimer’s disease. Their investigation shows that cognition can be blocked by the hostile inflammatory environment in the brains of patients with Alzheimer’s disease and that physical exercise can “clean up” that environment, allowing new nerve cells to survive and thrive and improving cognition in the Alzheimer’s mice.“In our study we showed that exercise is one of the best ways to turn on neurogenesis and then, by figuring out the molecular and genetic events involved, we determined how to mimic the beneficial effects of exercise through gene therapy and pharmacological agents,” said Rudolph Tanzi, director of the Genetics and Aging Research Unit, vice chair of the Department of Neurology, and co-director of the Henry and Allison McCance Center for Brain Health at MGH. Tanzi is the senior author of the paper published in Science.Lead author Se Hoon Choi of the Genetics and Aging Research Unit said, “While we do not yet have the means for safely achieving the same effects in patients, we determined the precise protein and gene targets for developing ways to do so in the future.”Adult neurogenesis — production of new neurons after the embryonic and, in some animals, neonatal periods — takes place in the hippocampus and another brain structure called the striatum. While adult hippocampal neurogenesis is essential to learning and memory, how the process impacts neurodegenerative conditions like Alzheimer’s has not been well understood. The MGH team set out to investigate how impairment of adult hippocampal neurogenesis (AHN) contributed to Alzheimer’s pathology and cognitive function in a mouse model, and whether increasing AHN could reduce symptoms. “It is not enough just to turn on the birth of new nerve cells; you must simultaneously ‘clean up’ the neighborhood in which they are being born …. Exercise can achieve that …” — Rudolph Tanzi, senior author The Daily Gazette Sign up for daily emails to get the latest Harvard news.last_img read more

Joe Pavelski free agency rumors: Veteran center expected to sign three-year deal with Dallas

first_imgAfter 13 years of calling San Jose home, Joe Pavelski is on his way to Dallas.According to TSN’s Bob McKenzie, the 34-year-old center is expected to sign a three-year contract with an AAV of $7 million. Pavelski led the Sharks with 38 goals and completed his eighth year with at least 60 points last season en route to a Western Conference Finals appearance.  As @TheFourthPeriod reported, it’s believed to be a three-year deal for Pavelski with an AAV around $7M:— Bob McKenzie (@TSNBobMcKenzie) July 1, 2019A former seventh-round pick by the San Jose, the Plover, WI native will receive the highest AAV of his career and join Tyler Seguin and Jamie Benn on the Stars’ roster of high-priced forwards. The reported value of the contract would absorb more than half of Dallas’ available cap space as they look to improve upon a 2018-19 campaign that resulted in a wild card playoff berth, which ended at the hands of the St. Louis Blues in the Westerns Conference Semifinals.NHL free agency tracker 2019: Full list of signings, best available playersThe Sharks decided to put most of their free agency money towards giving Erik Karlsson his eight-year, $92 million contract and with Kevin Lebanc and Timo Meier set to become restricted free agents there wasn’t enough in the budget to keep Pavelski.last_img read more

CSO Asks Legislature to Reject President Sirleaf’s Request

first_imgHon. J. Alex TylerSpeaker of the House of RepresentativesCapitol BuildingCapitol Hill, MonroviaDear Speaker Tyler:The Civil Society in Liberia writes to express its deepest concerns of a letter addressed to the Legislature from the President Ellen Johnson Sirleaf seeking extra-constitutional powers to respond to the ebola outbreak in Liberia.We are of the opinion that no one has the power or authority to suspend Article 1 of the Liberian Constitution regardless of the circumstances. When the framers of the Constitution fashioned Article 1 in the way they framed it, they were making clear that Constitutional power lies only in the people of the country:“All power is inherent in the people. All free governments are instituted by their authority and for their benefit and they have the right to alter and reform the same when their safety and happiness so require.”We fear that a move like this has the propensity to set a dangerous precedence for future governance of the country as unscrupulous persons can easily abuse it and plunge the country into chaos. Even now, there is a possibility of such a power being abused by the president.In regards to Article 12, Civil Society argues that The President does not need extra powers over this provision of the Constitution, and we are quite sure that Liberians do not have to be made slaves in order to end the scourge of the Ebola Virus Disease in the country.While we accept the necessity of restricting the movement of people in and out of the country on legitimate public health grounds, the power to do this should rest with the courts and not solely in the hands of the President. As before, concentrating such a power in the hands of one person can lead to the wanton abuse of the rights of the people of this country.Honorable Speaker, Article 14 is one of the bedrocks of our democracy and system of government. The Constitution has already indicated at this article how religious freedoms can be curtailed and the process through which it may be done. There is nowhere in this provision or anywhere else in the Constitution that any one individual is given the right to place restrictions on religion. That power is the sole preserve of the Liberian Legislature and the article clearly says that, “All persons shall be entitled to freedom of thought, conscience and religion and no person shall be hindered in the enjoyment thereof except as may be required by law to protect public safety, order, health. or morals or in the fundamental rights and freedoms of others.”On the President’s request to continue exercising powers restricting Article 15 rights, it is once more our considered opinion that such powers are best exercised through the Judiciary or the Legislature. There are already statutes which stop people from exercising this right irresponsibly. Even the Constitution provides safeguards. We agree that no one should be allowed to cause a state of panic in the country regardless of the reason. What we do not agree with is the power to restrict Article 15 rights should be left to one person’s discretion.As regards Article 17, it is well understood that public assemblies of large groups may not be a wise thing to do in the current health crisis especially as it relates to a disease like Ebola which spreads through close bodily contact. In spite of that fact, we still do not think that the power to restrict this right should be held by any one person. The government already exercises the people to stop people from demonstrating on grounds of a statute. The restriction on this right may continue to be enjoined in this manner.Mr. Speaker, we think it is an absolute violation of the Constitution to allow the President the right to continue exercising the powers she has requested you to endorse under Article 24. The Constitution, at this article, has already given the government the right to expropriate private property in a situation like this. What the Constitution has clearly not allowed is for such expropriation to be done without just compensation as the President has asked. The Constitution also does not give the President the power to remove the right of any such property owner except through a recourse to the courts.Finally Mr. Speaker and Honorable Members of the House of Representatives, the Emergency Powers provisions of the Constitution have been misconstrued in many corners of this country. Clearly Article 86b states that “A state of emergency may be declared only where there is a threat or outbreak of war or where there is civil unrest affecting the existence, security or wellbeing of the Republic amounting to a clear and present danger.” While the EVD presents a danger to Liberia, it does not meet the critical legal test (threat or outbreak of war or…civil unrest) to serve as the basis for declaring a state of emergency.Further, Articles 86a and 87 clearly state restrictions on the exercise of legislative powers. Article 88 makes it clear that at the time you voted to impose the state of emergency, included in your joint resolution with the Liberian Senate, there should have been all the justifications and restrictions necessary and justified for making the declarations. The constitution is clear when it says “…The Legislature shall within seventy two hours, by joint resolution voted by two thirds of the membership of each house, decide whether the proclamation of a state of emergency is justified or whether the measures taken thereunder are appropriate.”Mr. Speaker and Honorable Members of the House of Representatives,  In addition to the acknowledged facts that the letter seeks to limit basic freedoms, the Civil Society the following reasons for which the request should not be accepted.The circumstance in our country is now more in terms of health services, and the issues being proposed could not provide any more response to the ebola situation now in the country than the health services being provided.In addition, the proposal suggests the suspension of rights provided for under the state of emergency, but the time frame provided by the constitution has been exhausted, so we request that these measures be ignored.Mr Speaker,In conclusion, Civil Society like to note that the issues raised by the president do not seem to be considerate of the due respect for the constitution. It is our expectation that you would take the prudent decision of rejecting this request of President Sirleaf and remain on the path of promoting democracy in our country.Sincerely yours,Civil Society in LiberiaLancedell J. MatthewsOn Behalf of the OrganizationsShare this:Click to share on Twitter (Opens in new window)Click to share on Facebook (Opens in new window)last_img read more

Mayday, Mayday! ‘Get your car for free @ DMG’ giveaway gets underway

first_imgA major competition has kicked off at DMG Motors Donegal this month, where one lucky customer will win a free car!This May Day competition isn’t just for one day though, as people will have a whole year to get their names in the hat.Everyone who purchases a used car from DMG Motors between May 2019 and May 2020 will receive an entry to a draw to get the price of their car back. Finn Harps legend Kevin McHugh helped kick-start the campaign this week and explained how winning could be as easy as 1-2-3!The three-step entry is:1 – Buy a used car from DMG Motors Donegal Town 2 – Like DMG Motors on Facebook3 – Tag your friends in the Facebook offer page here: customer who buys a used car at DMG will receive a unique number on delivery which will be placed in the draw.The winner will be drawn independently on Friday 1st May 2020Stephen McCaul – General Manager of DMG Motors – with Kevin McHugh – Head of the Finn Harps AcademyAnd you’ll be spoilt for choice if you are looking for a used car at DMG Motors. They have a wide range of makes, years and price points to suit every driver. The team are always on hand to answer questions as they pride themselves on selling quality second-hand cars and abiding by the highest levels of customer service. So, if you’re thinking about a used car this year, there’s no better time to see what DMG Motors have for you. And there could be no better extra than the chance to win the price back for free! Browse the current stock now at: www.dmgmotors.ieSee the Facebook offer for giveaway T&Cs:, Mayday! ‘Get your car for free @ DMG’ giveaway gets underway was last modified: May 7th, 2019 by Staff WriterShare this:Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window)Click to share on LinkedIn (Opens in new window)Click to share on Reddit (Opens in new window)Click to share on Pocket (Opens in new window)Click to share on Telegram (Opens in new window)Click to share on WhatsApp (Opens in new window)Click to share on Skype (Opens in new window)Click to print (Opens in new window)Tags:carscompetitionDMG MOTORSDonegal TowndrawFinn Harps AcademygiveawayKevin McHughused carsvideolast_img read more

Warriors to rest Thompson, Green, Iguodala, Livingston vs. Suns

first_imgOAKLAND — Warriors coach Steve Kerr reimplemented a tactic he used in past seasons in hopes to keep his star players fresh. He has started rested them.The Warriors will sit All-Stars Klay Thompson and Draymond Green as well as established veterans Andre Iguodala and Shaun Livingston in Monday’s exhibition game against the Phoenix Suns at Oracle Arena. That leaves All-Stars Stephen Curry and Kevin Durant starting with third-year center Damian Jones, fourth-year forward Kevon Looney and …last_img

NFL Picks Week 9: 49ers edge Raiders while Rams, Patriots stay hot

first_imgCLICK HERE if you are having a problem viewing the photos on a mobile deviceLong story short, let’s dive into the second half of the NFL season with these Week 9 picks:49ers 27, Raiders 26: Neighborhood block party at Levi’s Stadium! Everyone bring your lone win, generous defense, suspect QB and under-fire coach. The Raiders are averaging one sack a game, and that bodes well if the 49ers debut Nick Mullens at quarterback or otherwise revert to C.J. Beathard with a bad wrist. Line: Raiders +2 …last_img

Semenya, Lyles cruise to Diamond League trophies

first_imgZurich, Aug 31 (AFP) South African Caster Semenya wrapped up another fantastic season by claiming the women’s 800m trophy in the Diamond League on Thursday as American sprint hope Noah Lyles took the 200m crown. “It was just fantastic,” said Semenya, who won in 1min 55.27sec, more than 2sec ahead of American Ajee Wilson in second. “It has been a long month of racing for me and I feel it on my body. “I am consistent at this level, but the world record is actually not on my mind,” said Semenya, the double Olympic champion (2012, 2016) and three-time world champion (2009, 2011, 2017) who is now unbeaten over the 800m since her elimination in the semi-finals of the 2015 worlds in Beijing. It was a fitting end to the season for the 27-year-old, who did a Commonwealth double in the Gold Coast early in the season but then came under the spotlight off the track as she turned to the Court of Arbitration for Sport (CAS) in her challenge of IAAF rules on testosterone levels in female athletes to be introduced in November. Under the new regulations, “hyper-androgynous”, athletes like Semenya would have to chemically lower their testosterone levels to be able to compete, something the 800m runner says is discriminatory and in violation of the IAAF’s constitution and the Olympic Charter. Lyles was one of the headline acts in Zurich and the 21-year-old made no mistake as he won the 200m in 19.67sec, just two-hundredths off his personal best set in Monaco last month. It was Lyles’ fifth win on the Diamond League circuit this season, with Turkey’s world and European champion Ramil Guliyev coming in second in 19.98sec.advertisement “I came here for the win and I did it, I’m very happy,” said Lyles. The women’s blue riband event saw Britain’s newly-crowned European champion Dina Asher-Smith, who struck triple gold in Berlin after also winning the 200m and taking the 4x100m relay with her British team, clocked 11.08sec to take second in the 100m. Nigerian Blessing Okagbare-Ighoteguonor having false started, Asher-Smith finished behind Murielle Ahoure in 11.01sec with another Ivorian, Marie-Josee Ta Lou, in third. “Before the African championships I had to pull out and I was so disappointed to miss out on them,” said Ahoure. “I wasn’t sure about my shape then. I wanted to do at least one more race and I’m so happy to come here and to win it.” – Walsh, Stefanidi shine -========================== In the field, New Zealand’s Tom Walsh wrapped up his shot put trophy with a meetig and Diamond League record of 22.60m. And Greece’s double defending title holder Ekaterina Stefanidi continued the form that saw her clinch European gold for a third successive title. Stefanidi, with the world, Olympic and European titles to her name, cleared a best of 4.87m to nudge out American Sandi Morris, who holds the season’s best. Disappointingly, Norwegian teenager Jakob Ingebrigtsen was a late withdrawal because of sickness, having himself only been named in the field as a late replacement. Aged just 17, he took gold in both the men’s 1500m and 5000m at the Berlin Euros, but in his absence in Zurich, Kenyan Timothy Cheruiyot timed 3:30.27 to beat out compatriot and current world champion Elijah Manangoi to defend his Diamond League trophy. China’s Lijao Gong having won the women’s shot put a day before the main action in Brussels, 15 Diamond League disciplines remain to be decided at a sell-out King Baudouin II stadium on Friday. (AFP) ATKATKlast_img read more